Sophie Ecclestone, Lauren Bell and Amy Jones will also miss the three-match series while Danni Wyatt-Hodge and Sciver-Brunt are absent as they manage their fitness and recovery.
England have named two uncapped players, seam bowler Grace Potts, 24, and wicketkeeper Kira Chathli, 27, in the 15-strong squad, while all-rounder Charis Pavely could make her 50-over debut having two T20s against Ireland in 2024.
Pace bowler Ryana MacDonald-Gay is included, having last played for England in the Ashes in early 2025, while 18-year-old spinner Tilly Corteen-Coleman, who finished as the joint-leading wicket-taker in this season's Hundred, is also selected.
"It has been an incredible summer for women's cricket already, and these three ODI matches against Ireland make up an important series for us to complete our summer," said head coach Charlotte Edwards.
"The focus has rightly been on T20 cricket for much of this year, but with a memorable run to the T20 World Cup final now behind us, this is a chance for players to display their 50-over skills and bank some valuable experience for the future.
"We have got plenty of exciting and talented cricketers in our game and this is an opportunity for some of them to push themselves further forward by hopefully contributing to England victories and putting pressure on future selection."
England squad and fixtures
Squad: Maia Bouchier (Hampshire), Alice Capsey (Surrey), Kira Chathli (Surrey), Tilly Corteen-Coleman (Surrey), Charlie Dean (capt, Somerset), Sophia Dunkley (Surrey), Lauren Filer (Durham), Dani Gibson (Somerset), Jodi Grewcock (Essex), Freya Kemp (Hampshire), Ryana MacDonald-Gay (Surrey), Charis Pavely (Warwickshire), Grace Potts (Lancashire), Mady Villiers (Durham), Issy Wong (Warwickshire)
First ODI: Leicester, 1 September, 13:00 BST
Second ODI: Derby, 3 September, 13:00 BST
Third ODI: Worcester, 6 September, 10:30 BST
